The bcl-2 Gene, Follicular Lymphoma, and Hodgkin's Disease
نویسندگان
چکیده
منابع مشابه
Involvement of bcl-2 gene in Japanese follicular lymphoma.
A t(14;18) (q32;q21) chromosome translocation is closely associated with the follicular lymphoma, which is prevalent in the United States, and the t(14;18) causes the juxtaposition of a bcl-2 gene on chromosome 18 with an immunoglobulin heavy-chain gene locus on chromosome 14. Genomic DNAs from 30 Japanese patients with follicular lymphoma were examined for the molecular features by Southern bl...
متن کاملThe bcl-2 oncogene in Hodgkin's disease arising in the setting of follicular non-Hodgkin's lymphoma.
Expression of the bcl-2 proto-oncogene on chromosome 18 is deregulated by the 14; 18 chromosomal translocation, an abnormality that is consistently associated with follicular non-Hodgkin's lymphomas (NHL). Because bcl-2 is believed to function by prolonging cell survival rather than by increasing proliferation, the presence of t(14; 18) in Hodgkin's disease (HD) would have profound implications...
متن کاملMorphologic transformation of follicular lymphoma is associated with somatic mutation of the translocated Bcl-2 gene.
Follicular lymphoma (FL) is a low-grade B-cell non-Hodgkin's lymphoma (NHL) that frequently transforms into diffuse aggressive NHL. The majority of FLs display a t(14; 18) translocation that places the bcl-2 gene into juxtaposition with the lg heavy-chain (H) gene locus. Morphologically transformed malignant FL cells retain their t(14;18) translocation and may acquire additional genetic abnorma...
متن کاملAnalysis of the structure, transcripts, and protein products of bcl-2, the gene involved in human follicular lymphoma.
We have determined that the bcl-2 (B-cell leukemia/lymphoma 2) gene is transcribed into three overlapping mRNAs, and we have cloned bcl-2 cDNA sequences. Sequence analysis of the bcl-2 cDNA clones and comparison of their sequences to their genomic counterparts indicate that the bcl-2 gene contains at least two exons. The three bcl-2 transcripts, which are 8.5, 5.5, and 3.5 kilobases (kb) long, ...
متن کاملThe synthesis of Bcl-2 and other proteins in the neoplastic follicles of follicular lymphoma.
The bcl-2 proto-oncogene was discovered at the chromosomal breakpoint of the t(14;18) translocation found in human follicular lymphoma; t(14;18) juxtaposes the bcl-2 gene from chromosome 18 with the immunoglobulin heavy chain (IGH) locus on chromosome 14. This creates a bcl-2–IGH fusion gene that is markedly deregulated, resulting in the overproduction of bcl-2 RNA and protein. bcl-2 has the on...
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ژورنال
عنوان ژورنال: JNCI Journal of the National Cancer Institute
سال: 1990
ISSN: 0027-8874,1460-2105
DOI: 10.1093/jnci/82.10.808